Sophie's CV




  1. Study in vivo and in vitro acute effects of infection and inflammation on metabolism.
  2. Use gas chromatography/mass spectroscopy techniques to evaluate effects of HIV drugs on rates of human glucose production, lipolysis, and de novo lipogenesis in stable isotope tracer infusion studies.
  3. Implement a method for isolating VLDL and HDL associated lipoproteins to determine VLDL and HDL kinetics during tracer infusion studies in humans.
  4.  Investigate changes in lipids and lipoprotein size/composition in patients with rheumatoid arthritis.


  1. Feingold KR, Grunfeld C, Heuer JG, Gupta A, Cramer M, Zhang T, Shigenaga JK, Patzek SM, Chan ZW, Moser A, Bina H and Kharitonenkov A. “FGF21 in Increased by Inflammatory Stimuli and Protects Leptin Deficient ob/ob Mice from the Toxicity of Sepsis.” Endocrinology. 2012 March. In press.
  2. Endotoxin, zymosan, and cytokines decrease the expression of the transcription factor, carbohydrate response element binding protein, and its target genes. Feingold KR, Shigenaga JK, Patzek SM, Chui LG, Moser A, Grunfeld C. Innate Immun. 2011 Apr;17(2):174-82. 
  3. ADRP/ADFP and Mal1 expression are increased in macrophages treated with TLR agonists. Feingold KR, Kazemi MR, Magra AL, McDonald CM, Chui LG, Shigenaga JK, Patzek SM, Chan ZW, Londos C, Grunfeld C. Atherosclerosis. 2010 Mar;209(1):81-8. Epub 2009 Sep 2.PMID: 19748622 [PubMed - indexed for MEDLINE] Related citations
  4. The acute effects of HIV protease inhibitors on insulin suppression of glucose production in healthy HIV-negative men. Lee GA, Schwarz JM, Patzek S, Kim S, Dyachenko A, Wen M, Mulligan K, Schambelan M, Grunfeld C. J Acquir Immune Defic Syndr. 2009 Oct 1;52(2):246-8.PMID: 19680131 [PubMed - indexed for MEDLINE] Related citations
  5. Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm. Feingold KR, Moser A, Patzek SM, Shigenaga JK, Grunfeld C. J Lipid Res. 2009 Oct;50(10):2055-63. Epub 2009 May 14.PMID: 19443862 [PubMed - indexed for MEDLINE]Free PMC Article Free text Related citations
  6. A genetic screen for suppressors of a mutated 5' splice site identifies factors associated with later steps of spliceosome assembly. Dassah M, Patzek S, Hunt VM, Medina PE, Zahler AM. Genetics. 2009 Jul;182(3):725-34. Epub 2009 Apr 20.PMID: 19380478 [PubMed - indexed for MEDLINE]Free PMC Article Free textRelated citations
  7. Inflammation stimulates the expression of PCSK9. Feingold KR, Moser AH, Shigenaga JK, Patzek SM, Grunfeld C. Biochem Biophys Res Commun. 2008 Sep 19;374(2):341-4. Epub 2008 Jul 16.PMID: 18638454 [PubMed - indexed for MEDLINE] Free PMC Article  Free text Related citations
  8. Poster of work on HIV protease inhibitors presented at 8th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Sydney, Australia, July 22-26 2007.
  9. Poster Presentation: “Lipoprotein Changes in Rheumatoid Arthritis” at UTHSCSA Research Day 2010.

Other Interests

  1. Chemistry Teaching Assistant, UCSC 2004
  2. SFGH Volunteer 2007-2009
  3. President of the Pathology Interest Group, UTHSCSA
  4. Secretary of Bicycle Club, UTHSCSA
  5. Biochemistry Tutor, UTHSCSA 2010           
  6. Diversity Committee Student Representative, UTHSCSA 2010-2013

Community Service

  1. Alpha Home: student-run clinic for women with chemical dependencies, 2010 - present
  2. San Antonio Metropolitan Ministry, Inc. (SAMMinistries): student-run clinic for homeless families, 2010
  3. Susan G Komen for the Cure: Fundraising for annual Powder Puff game where all proceeds donated to Susan G Komen, 2010
  4. San Francisco General Hospital: Emergency Department Volunteer,  2007 – 2009